Long–Term Effects of Energy-Restricted Diets Differing in Glycemic Load on Metabolic Adaptation and Body Composition*
Sai Krupa Das*, 1, Cheryl H. Gilhooly1, Julie K. Golden1, Anastassios G. Pittas2, Paul J. Fuss1, Gerard E. Dallal1, Megan A. McCrory3, Edward Saltzman1, Susan B. Roberts1
Identifiers and Pagination:Year: 2008
First Page: 76
Last Page: 85
Publisher Id: TONUTRJ-2-76
Article History:Received Date: 30/05/2008
Revision Received Date: 26/06/2008
Acceptance Date: 02/07/2008
Electronic publication date: 7/8/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A randomized controlled trial of high glycemic load (HG) and low glycemic load (LG) diets with food provided for 6 months and self-administered for 6 additional months at 30% caloric restriction (CR) was performed in 29 overweight adults (mean±SD, age 35±5y; BMI 27.5±1.5 kg/m). Total energy expenditure (TEE), resting metabolic rate (RMR), fat and fat free mass (FFM), were measured at 3, 6 and 12 months. Changes in TEE, but not changes in RMR, were greater than accounted for by the loss of FFM and fat mass (P=0.001-0.013) suggesting an adaptive response to long-term CR. There was no significant effect of diet group on change in RMR or TEE. However, in subjects who lost >5% body weight (n=26), the LG diet group had a higher percentage of weight loss as fat than the HG group (p<0.05), a finding that may have implications for dietary recommendations during weight reduction.