The Effect of Metabolism-Boosting Beverages on 24-hr Energy Expenditure

L.M. Davis*, 1, C.D. Coleman1, W.S. Andersen1, L.J. Cheskin2
1 Medifast Inc., Research & Development, 11445 Cronhill Drive, Owings Mills, MD 21117, USA
2 Johns Hopkins Bloomberg School of Public Health, Department of International Health, Division of Human Nutrition, Baltimore, MD 21205-2179, USA

© 2008 Davis et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Medifast Inc., Research & Development, 11445 Cronhill Drive, Owings Mills, MD 21117, USA; Tel: 410-504-8220; Fax: 410-504-8221;


The effect of thermogenic meal replacement beverages (TMRB) containing 90 mg EGCG and 100 mg of caffeine on resting energy expenditure (REE) was tested. Thirty adults (19 women, 11 men) were stratified into 3 groups: lean (n=10, BMI 21.5 ± 2.1); overweight/obese (OW) (n=10, BMI 29.8 ± 2.7); or weight maintainers (WM) (n=10, BMI 28.8 ± 4.0). Following an overnight fast, baseline measurements, including REE via indirect calorimetry, were performed. REE was repeated at 30, 60, 90, and 120 minutes after consuming a TMRB. Appetite was assessed via visual analogue scale at baseline, 30 minutes and 120 minutes after the TMRB. Mean 24-hour REE was increased 5.9 ± 2.5% overall (p=0.000), 5.7 ± 3.1% among lean subjects (p=0.0002), 5.3 ± 1.4% among OW subjects (p=0.000), and 6.8 ± 2.7% among WM (p=0.0007). Appetite was significantly reduced 30 minutes after the TMRB (p=0.0002). TMRB appear to be a promising weight control tool.

Keywords: Obesity, metabolism, weight loss, energy expenditure, thermogenesis.